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Author Topic: Epogen, Procrit, and Aranesp  (Read 3905 times)
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mainecoonpeg
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« on: February 17, 2010, 02:15:54 PM »

The following information pertains to human patients.
This is something that I think vets should be made aware of as they often prescribe Epogen for CRF kitties with anemia.

I do certainly realize that kitties are not small humans but I do think it's worth further investigation to see if CVM is thinking along the same lines............


http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm200297.htm

Drug Safety Communication: Erythropoiesis-Stimulating Agents (ESAs): Procrit, Epogen and Aranesp
Safety Announcement

Additional Information for Patients

Additional Information for Healthcare Professionals and Hospitals: ESA use in cancer

Additional Information for Healthcare Professionals: non-cancer use of ESAs

Table of Key Safety Studies

 

Safety Announcement
The FDA is requiring all drugs called Erythropoiesis-Stimulating Agents (ESAs) to be prescribed and used under a risk management program, known as a risk evaluation and mitigation strategy (REMS), to ensure the safe use of these drugs. The ESAs that are part of the REMS are marketed under the names Epogen, Procrit, and Aranesp. FDA required Amgen, the manufacturer of these products, to develop a risk management program because studies show that ESAs can increase the risk of tumor growth and shorten survival in patients with cancer who use these products. Studies also show that ESAs can increase the risk of heart attack, heart failure, stroke or blood clots in patients who use these drugs for other conditions.

ESAs work by stimulating the bone marrow to produce red blood cells. ESAs are approved for the treatment of anemia (low red blood cells) resulting from chronic kidney failure, chemotherapy, certain treatments for Human Immunodeficiency Virus (HIV), and also to reduce the number of blood transfusions during and after certain major surgeries.
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JJ
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« Reply #1 on: February 17, 2010, 05:16:53 PM »

Using this (as in humans) can cause the tumors to grow and shorten the life of someone using chemo to eradicate cancer and this drug will undo what the chemo is trying to do by making the tumors grow, blood clots, heart failure heart attacks - this sure has a lot of dangerous side effects.

These side effects - how would they do more damage than help a lil kitten if used? Is there not a natural method that could be employed for treatment of anemia?
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mgt
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I will see you soon my little boy! Momma loves you


« Reply #2 on: February 17, 2010, 11:29:22 PM »

I remember my vet wanted to start Leeah on Procrit for urinary incontinence and I refused... I didn't like the idea at all... now looking back I am glad I followed my gut.  She stopped the incontinence on her own...  I have no clue why it started all of a sudden to begin with but it was around the 2007 summer (she was 3 at the time with no previous history of incontinence).
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NedF
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« Reply #3 on: February 18, 2010, 12:53:56 AM »

My vet recommended Epogen for Thunder's anemia. It is used for cats with severe non-regenerative anemia. The side effects really weren't a big concern since without the Epogen she wouldn't have survived very long. It worked for her and I could see she felt better with her anemia gone. I would use it again if I had a kitty in the same circumstance. In fact, my one regret in taking care of Thunder was not using the Epogen when the vet first suggested it.
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