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Author Topic: (Melamine Suspected) Chinese Officials Say Baby Formula Tied to Kidney Stones  (Read 278899 times)
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« Reply #1440 on: January 14, 2009, 11:34:36 AM »

I just posted a new abstract about the PFR  and saying how more male cats and rats were affected.... 

About the boys being more prone, interesting. There could be a clue in there. I hope it is explored since it looks like it will be a year or more before we can get enough melamine out of the food system. Didn't they say something about increasing the acidic level of urine or something to dissolve stones?

I remember reading that bladder cancer was found in male rats, not females, just along this train of thought.   But here is the info about animal studies.  I wonder if the male connection might be endocrine or anatomical differences.

Potential symptoms: Irritation of eyes, skin, and mucous membranes; dermatitis; in animals: chronic inflammation of kidneys (female rats); ulceration of urinary bladder epithelium (mice), urolithiasis (rats and mice); bladder cancer (male rats).


“Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it’s the only thing that ever has.” — Margaret Mead

United we stand     Divided we fall....
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Posts: 181

« Reply #1441 on: January 14, 2009, 11:41:54 AM »


Interesting article. I remember suggesting when petconnection was doing their counter on the web site back in 2007, on pets affected by melamine, that it may be helpful to break it down into male and female numbers as well as cat and dog.

I know the site was unable to do that, but maybe some other reporting contacts may have a more detailed breakdown of the male/female statistics. Not sure where to try for this info, but I have always wondered. My male kitty was starting to show effects back in April 2007, but my girlie seemed to be okay and they both ate identical foods. (After putting them onto home-cooking since then they have both been fine..knock on wood)
« Reply #1442 on: January 17, 2009, 05:10:23 AM »

A very kind individual sent a copy of the study. For those interested in looking for it, the conclusions
of the study with regards to affected Chinese infant patients

The study finds that there is a strong correlation between urinary melamine level and stone sizes.
Melamine alone (without cyanuric acid) can cause renal stones in infants, no correlation between urinary
melamine and cyanuric acid is found.

A safety melamine urine concentration of 7.1 ?g/mmol creatinine has been established. (**that's 7.1 micrograms of melamine, ug)

The article citation is:

"Diagnosis and spectrum of melamine-related renal disease: Plausible mechanism of stone formation in humans"

Ching-Wan Lam, Lawrence Lan, Xiaoyan Che, Sidney Tam, Samson Sai-Yin Wong, Yue Chen, Jing Jin, Shao-Hua Tao,

Xiao-Ming Tang, Kwok-Yung Yuen, Paul Kwong-Hang Tam

PII: S0009-8981(09)00005-9

DOI: doi: 10.1016/j.cca.2008.12.035

Reference: CCA 11291

To appear in: Clinica Chimica Acta

I believe the conclusions here are different in important ways from what veterinarians have
said about the 2007 recalls {if applicable to our pets} and the United States FDA has been saying publicly
about U.S. infant formula and melamine level safety. To the best of my knowledge, this is the first
medical study of the victims of the Chinese infant formula scandal of 2008, and it would seem to
indicate rapid and immediate reassessment of melamine safety levels in all infant formula is called for.


**Correction: that melamine safety level is 7.1 micrograms (Unicode scientific symbol) ug/mmol of creatinine in urine. Above that
level, kidney stones are more likely to form according to this study.
« Last Edit: January 17, 2009, 06:11:34 AM by 3catkidneyfailure » Logged
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« Reply #1443 on: January 17, 2009, 09:43:34 AM »

3cat, is that 7.1 like 7 grains of sand in a million?
« Reply #1444 on: January 17, 2009, 10:54:59 AM »

Sent you a PM, straybaby. I math/metric handicapped.
« Reply #1445 on: January 17, 2009, 05:10:04 PM »

Poco, I have the following reservations:
The copy I received came in response to a personal request for patient assistance with no
privacy disclaimer attached by the individual who sent it to me.

The conclusions I quoted were previously published by the Hong Kong Standard newspaper and
do accurately reflect the study's conclusions relating to human infants and melamine levels without
the presence of cyanuric acid or other melamine analogues.
Discovery may deliver easy kidney stone test (from January 14, 2009)

I would post the entire article for everyone to read, but I don't know if that would violate some
copyright law and cause problems -- bugaboo I don't know enough about.
So my forwarding the study may not be a good idea. If it's available for purchase online, probably not
a good idea. Otherwise I would like to post the study very much to get some assistance with questions
relating current government statements on infant melamine safety and WHO statements
on infant melamine safety to the levels discussed here. But there definitely is a conflict between this study's
conclusions and what some government agencies are declaring as safe levels of melamine or combined melamine/melamine
analogues in human infant formula that needs to be resolved as soon as possible. The seeming assumption that
it takes both melamine and cyanuric acid to cause kidney stones/renal failure is most definitely in conflict with study conclusions.
November 28, 2008 FDA melamine risk assessment infant formula
This value of 1.26 ppm is rounded down to 1.0 ppm melamine to provide an additional margin of safety.
melamine toxicity on page 3
Triggered by the event of melamine contamination in Chinese dairy products and dairy containing products (including infant formula) the United States Food and Drug Administration (US FDA), Health Canada and the European Food Safety Authority (EFSA), carried out new Risk Assessment/Statement on melamine in food. A new interim safety and risk assessment of melamine and melamine-related compounds in food, including infant formula, has been issued by the US FDA on 3 October 2008 (and updated 28 November). The TDI recommended for food and food ingredients other than infant formula is of 0.063 mg per kg of body weight per day.

An updated statement by EFSA on the risk for public health due to the presence of melamine in infant milk and other milk products in China has been issued on 24 September 2008. In this statement the TDI of 0.5 mg per kg of body weight is still applied.

Health Canada announced a risk assessment for melamine in foods containing milk and milk-derived ingredients where a toxicological reference dose for melamine of 0.35 mg per kilogram body weight per day is established.

Conversions between 7.1 micrograms of melamine per millimol of creatinine in infant urine to milligrams of melamine per kilogram of
body weight per infant day by any country's declared melamine safety standards are over my head for sure. So I'm kind of stuck.
What's posted here can be forwarded.

Trying your links, Poco. Thank you.
« Last Edit: January 17, 2009, 07:15:11 PM by 3catkidneyfailure » Logged
« Reply #1446 on: January 21, 2009, 06:24:16 PM »

Health Canada finds traces of melamine in most infant formula
Agency considers products to be safe
By Sarah Schmidt, Canwest News ServiceDecember 11, 2008

Three-quarters of infant formula for sale in Canada this fall had trace amounts of melamine and the highest levels were found in an organic product sold by a Canadian company, Health Canada reported Thursday.

The "snapshot"

House brands from Loblaws, Wal-Mart, Sobeys and Shoppers Drug Mart sold infant formula with traces of melamine as high as 0.094 to 0.183 ppm. One batch of Costco's Kirkland brand was tested, in which Health Canada found no detectable levels.

The four corporate giants accounting for most of infant formula sales -- Abbott Laboratories, Nestle, Mead Johnson and H.J. Heinz -- also sold products with traces of melamine, but at lower levels than these house brands.

All six Heinz products contained traces of melamine, as did eight of 17 Nestle products. Eleven of 18 types of formula produced by Abbott and sold under the Similac and Isomil brands had traces, compared to 14 of 19 Mead Johnson products, sold under Enfamil, Enfapro and Enfagrow brands.

« Reply #1447 on: January 21, 2009, 07:39:17 PM »

So when, besides this University of Hong Kong study, is some government
regulator going to establish "safe" levels of melamine exposure for infants
in baby formula based on studies of Chinese victims, some of whom were
exposed for years apparently, and not rat study extrapolations? Kids are
not rats ... rant, rant, rant
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Posts: 3200

« Reply #1448 on: January 22, 2009, 03:40:28 AM »

here's a start at risk vs benefit concerning whether or not to "adulterate"... Tongue Lips sealed

“Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it’s the only thing that ever has.” — Margaret Mead

United we stand     Divided we fall....
« Reply #1449 on: January 22, 2009, 04:59:44 AM »

Two condemned to death for role in China milk crisis:

« Reply #1450 on: January 22, 2009, 08:01:05 AM »

Oddly enough, a Trivial Pursuit question recently came up regarding the country
that had carried out over 3000 executions in 2005, I think it was. The answer
was China. I'm not advocating that here in the U.S. necessarily, although premeditation
would sure seem to justify death in some food/drug adulteration cases, but as these penalty
articles make clear, the United States needs much more serious penalties
for manufacturers/importers/corporations who adulterate food/drugs and government agencies
who fail to safely regulate the food/drug supply need to also be indicted and
changed drastically:

From the New York Times article above in Carol's post
Tian Wenhua, the 66-year-old former chairwoman of the Sanlu Group, one of China’s largest dairy companies, was sentenced to life in prison for her failure to stop producing and selling the tainted goods even after her company learned that the products were flawed.

Ms. Tian was the highest-ranking corporate executive to have been brought to trial in the scandal. She pled guilty in December to charges that she had acted improperly in the case and was also fined about $3 million. All the deaths in the milk scandal so far have been linked to Sanlu, which was found to have sold the milk products with the highest concentrations of melamine.

Three other former executives at Sanlu were sentenced to 5 to 15 years in prison. One of those executives, Wang Yuliang, had appeared at the court in Shijiazhuang in December in a wheelchair after what the Chinese state-controlled media said was a failed suicide attempt.

The tough sentences were the government’s latest effort to deal with a scandal that erupted last September, triggering a global recall of Chinese-made dairy products, shaking consumer confidence and devastating the nation’s fast-growing dairy industry.

But parents of some victims of the scandal protested Thursday afternoon outside the courthouse in Shijiazhuang, where Sanlu is headquartered, saying they were dissatisfied with the verdict.

“I feel sorry for them, but they are just scapegoats,” said Liu Donglin, 28, who said his 21-month old son suffered from kidney stones after drinking tainted milk formula. “The ones who should take the responsibility are the government, like the quality supervision bureau and the Health Ministry. I spent nearly $3,000 taking care of my son and the government only compensated me with $300.”

Some lawyers and victims of the scandal have accused Beijing of failing to properly regulate the nation’s dairy industry and some believe the government covered up the scandal before the Beijing Olympics last August, disclosing the news in September.

« Last Edit: January 22, 2009, 08:07:42 AM by 3catkidneyfailure » Logged
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« Reply #1451 on: January 22, 2009, 01:25:12 PM »

Scientists develop test for melamine in milk
Wed Jan 21, 2009 4:52pm EST
CHICAGO (Reuters) - U.S. researchers have developed a quick way to test milk for the presence of melamine, an industrial chemical found last year in milk in China that killed at least six children and made thousands sick.

Researchers at Purdue University in Indiana said on Wednesday the method can detect tiny traces of the chemical in liquid and powdered milk in about 25 seconds.

The analysis method uses a simplified version of a mass spectrometer, a tool that can be used to separate and identify molecules in compounds.

The team developed the tool specifically to detect melamine, which was also found in contaminated pet food that killed thousands of dogs and cats in the United States in 2007.
« Reply #1452 on: January 22, 2009, 01:50:25 PM »

shawdowmice, post this article everywhere. 25 seconds. what a boone to concerned
parents. Would this include baby formula samples? Not clear in the article.
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Posts: 554

« Reply #1453 on: January 22, 2009, 03:42:03 PM »

More details from the unversity's site ....

January 21, 2009

Purdue technology detects contaminant in milk products
WEST LAFAYETTE, Ind. - Detecting melamine
in milk products
Download photo
caption below
A new analysis method can detect the kidney-damaging chemical melamine, used to contaminate infant formula in China last September, at very low levels within a matter of seconds.
A research team at Purdue University created the analysis method to detect levels of melamine in the low parts-per-billion in milk and milk powder in about 25 seconds.


"This situation created an immediate need for an analytical method that is highly sensitive, fast, accurate and easy to use," said R. Graham Cooks, Purdue's Henry B. Hass distinguished professor of chemistry, who led the team that developed the analysis method. "We took it as a challenge to use simpler instrumentation and to develop a faster method that allows the testing to be done on site and does not require pretreatment of samples."

In addition to Cooks, the team includes Guangming Huang, a postdoctoral research associate, and Zheng Ouyang, an assistant professor of biomedical engineering. A paper detailing their work was published online in the journal Chemical Communications and will appear in the next issue of the journal.


High-throughput trace melamine analysis in complex mixtures

Guangming Huang, Zheng Ouyang, and R. Graham Cooks

Ambient ionization using a low-temperature plasma (LTP) probe combined with tandem mass spectrometry (MS/MS) allows detection and quantitation of melamine in milk powder, whole milk and other products at levels down to low ppb in analysis times of a few tens of seconds.
« Reply #1454 on: January 22, 2009, 06:05:46 PM »

Doesn't look like, with a probe and a spectometer, it's a home test kit, does it? But
maybe cheaper for producers than the half-million dollar melamine detection machines
that came out in 2007. Maybe cheap enough to put melamine on the food industry's
radar screens.
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