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Author Topic: melamine found in US made baby formula  (Read 2363 times)
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Poco
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Ah, the dilution factor!


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« Reply #150 on: December 01, 2008, 09:23:18 PM »

I got a reply email from Jean Halloran of Consumers Union. Has one of those
confidential disclaimers on it. So I can't share.

Got a reply email from Cedars Sinai saying they don't have the capability and
in their opinion most hospitals don't to test for melamine crystals in human
urine. Also has confidential disclaimer on it.

Contacted Antec Labs to inquire about ability to use microalbuminuria test on
human urine sample. Antec is not allowed to test human products by law, so
said customer service rep.

Just frustrated as all get out. Want a simple test independently performed and
striking out so far.

Did you see this, 3cat?  There were a lot of posts following it.

http://www.adoptmed.org/topics/melamine-and-chinese-adoptions.html

They know a lot about this area.  They aren't recommending routine urine tests for children adopted from China right now, but seem to know a lot about those tests.  They could perhaps point you in the right direction to find them.

"As for specific testing for melamine itself in blood or urine, we are not doing that at this time. Such testing is investigational and hard to come by, and given the expected fairly rapid excretion of melamine, may not be of much clinical use. Plus, children may be exposed to insignificant amounts of melamine from other sources, which would complicate interpretation of results."

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3catkidneyfailure
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« Reply #151 on: December 04, 2008, 01:55:35 PM »

FDA test results page on infant formula:

http://www.fda.gov/oc/opacom/hottopics/melamine/testresults.html
Domestic Infant Formula Testing Results
Importer or Inspectors Description
 Manufacturer
 Specific Status
 Melamine
 Cyanuric Acid

What does the FDA mean by "importer or inspectors description"?
I thought baby formula was all domestically made?
 
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petslave
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« Reply #152 on: December 04, 2008, 05:58:22 PM »

Good question 3cat.  Must be some imports in there.  What's the difference between Nestle Nutrition and Nestle USA?  And why do some not even have brand names, are those for institution use?  They must not be sold to the public without a name, or maybe they are repackaged with a name?  Maybe those are the imports. 

They talk about minimum amounts and everything below that is safe.  But, like someone said earlier, if you happened to feed the two forumlas with cyanuric acid and melamine, it seems like it wouldn't matter how small of an amount is in there, the two chemicals should precipitate and form crystals.  And then of course there is urea which is in the body already.
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straybaby
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« Reply #153 on: December 04, 2008, 06:13:42 PM »

3Cat,

did you see this?
Quote
FDA's Testing Methods

The FDA Field laboratories are using LC-MS/MS methods that are capable of determining melamine and cyanuric acid at levels of 0.25 ppm in powdered infant formula and other dairy-containing food products or ingredients. These and a GC/MS method for melamine and its analogues are:

    * Melamine Methodology

          o Determination of Melamine and Cyanuric Acid Residues in Infant Formula using LC-MS/MS
          o Interim Method for Determination of Melamine and Cyanuric Acid Residues in Foods using LC-MS/MS
          o GC/MS method for melamine and analogues

it's at the bottom of this link:

http://www.fda.gov/oc/opacom/hottopics/melamine.html#testing

and the determination methods are linked. I was also curious about the unlabeled ones, but institution use sounds right. I also thought perhaps they were private label for someone.

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JJ
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« Reply #154 on: December 04, 2008, 10:50:51 PM »

Nice find straybaby. When I clicked on one of the topics found this about the test: developed by the Center for Veterinary Medicine (CVM) has been adapted for use with infant formula. Test was developed due to the pet food in 2007 from a couple paragraphs in the topic.
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Poco
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Ah, the dilution factor!


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« Reply #155 on: December 05, 2008, 01:25:08 AM »

I think the veterinary toxicologist talking here might be the one going to work on the irradiated cat food problem.  Somehow this bit of a listserver got out on Google.
Not good that there seems to be no way to stop the harm once you ingeset this.  Also the second post by the former FDA employee indicates that the dairy industry will not be testing for protein content in a way that will detect melamine.  Bet feed is too expensive for them to look for trouble unless someone actually regulates them.

http://lists.unc.edu/read/archive?id=4806894
"As far as I can find out, tripolycyanamide is another name for
melamine. The problem which exists is the contamination is not with
pure melamine, but with melamine and the other melamine related
compounds (MARC), one of which is cyanuric acid. When animals and
people ingest the crude product as was the case in the pet food and is
apparently the same as is happening in the infant formulas
, the
compounds are absorbed via the digestive tract and get into the blood.
I do not know if the two compounds form crystals in the blood or wait
until they get more concentrated in the urinary tubules. I suspect the
latter but do not know for sure. Melamine and cyanuric acid combine
with strong hydrogen bonding giving rise to the crystals. These
crystals cause a physical blockage of individual nephron tubules,
starting where the collecting ducts empty into the calyx of the
kidney. These crystals start irritating the tubular epithelium
initiating morphologic changes causing the epithelial cells to
enlarge. As the crystals accumulate, they cause a physical blockage of
the individual tubules. When a sufficient number of tubules are
blocked, renal functions becomes impaired.

Pure melamine is relatively non-toxic. the LD50 is around 4,000 mg/kg
in rats. I don't have the papers in front of me, but toxicity of
melamine to dogs is relatively low, also. Chronically, melamine causes
transitional cell carcinomas in the urinary bladders of rats.


I don't know of anything that can be used for prevention as there is
no metabolism of the melamine by monogastrics. Therefore metabolic
blocking agents would be of no value in individuals having ingested
the products
."




"Good Afternoon All,
Q: 1) What kind of protein assay do they confound?

Kjeldahl Methods Is the chemistry

Q: easy  enough that a clinician can learn it?

Yes, it is fairly basic, it is a total nitrogen determination

Q: Is the dairy/agriculture industry moving to another protein assay?

Doesn't appear to be

....
xxxxxxxxx worked for FDA during the 'pet food' issue.
"
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straybaby
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« Reply #156 on: December 05, 2008, 03:02:48 AM »

Quote
Not good that there seems to be no way to stop the harm once you ingest this.

I think this is where the FDA is really counting on the "dilution factor". We pass more than we retain. How do we like them odds?!

Somewhere in one of our threads, isn't there something about how this attaches to the inner workings of our bodies? This is different than "normal" stones, I think, in that this is a foreign body we are ingesting that is causing a reaction vs the more "natural" forming of stones in the bladder or kidney. I'm sure if we keep our bodies hydrated and flushed, we're a bit better off, but I'm not sure if it's as effective as "normal" stone prevention. We can also combat "normal" stone formation through diet. So far, the only thing I've heard in our bodies that might effect melamine is uric acid which we produce. We can control that, but we can't control melamine and MARC. And even if we eventually do pass most of it, what damage has it done in the meantime? Are damaged cells going to manifest into another issue? Is there residue that could cause cancer/tumors? Would the body be more apt to form stones due to trace or residue left in the body from uric acid that could be a forming point? Can the FDA answer any of these questions and back up the answer with facts?

Note: I'm basing my thoughts on what I know about blocking cats and Dalmatians.
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3catkidneyfailure
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« Reply #157 on: December 06, 2008, 08:17:46 AM »

straybaby, they can't tell you any answers because they're not looking for it.
Like China, it's cheaper to pay for the dead infants and babies.

Most I'm getting out of my grandson's urologist is an ultrasound if we're lucky
and can get insurance to approve it.
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JJ
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« Reply #158 on: December 06, 2008, 10:23:12 AM »

Sure might be cheaper to pay for the dead but they have the courts against them in being able to have compensation for a company causing their loss.
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trudy1
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« Reply #159 on: December 06, 2008, 04:34:51 PM »

Make sure to read the whole thing.


http://www.merck-chemicals.com/melamine-analysis-in-food/c_Ab.b.s1OpZIAAAEcvvpyz57S?WT.srch=1&WT.mc_id=MC000033

Merck Chemicals

Melamine Analysis in Food ZIC®-HILIC technology from Merck increases food safety
New FDA method for detecting melamine and cyanuric acid in infant formula uses Merck SeQuant™ ZIC®-HILIC chromatography column

The contamination of food with melamine can cause severe illness – especially to children. Therefore, a reliable method is needed to determine melamine residues and related potential contaminations in food and particularly in milk products for children. Merck SeQuant™ ZIC®-HILIC technology offers a solution.

Reliable and sensitive: FDA recommends SeQuantTM ZIC®-HILIC from Merck
Recently, the U.S. Food and Drug Administration (FDA) announced that it has developed a method for simultaneously detecting residues of melamine and cyanuric acid in infant formula using the chromatography column SeQuantTM ZIC®-HILIC from Merck. The FDA regulates, among other things, the safety of foods in the U.S. Recommendations of the FDA receive global attention and are often adopted by national authorities in other countries.
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trudy1
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« Reply #160 on: December 06, 2008, 04:38:14 PM »

This might be worth looking at.


http://www.emsl.com/Index.cfm?nav=Home
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3catkidneyfailure
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« Reply #161 on: December 07, 2008, 10:02:49 AM »

Have tried every Congressional office and FDA and NIH and CDC. None of them want
to know if melamine is causing harm to infants. Just unbelievable.
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mainecoonpeg
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« Reply #162 on: December 07, 2008, 10:08:27 AM »

Quote from Straybaby

"Somewhere in one of our threads, isn't there something about how this attaches to the inner workings of our bodies? This is different than "normal" stones, I think, in that this is a foreign body we are ingesting that is causing a reaction vs the more "natural" forming of stones in the bladder or kidney. I'm sure if we keep our bodies hydrated and flushed, we're a bit better off, but I'm not sure if it's as effective as "normal" stone prevention. We can also combat "normal" stone formation through diet. So far, the only thing I've heard in our bodies that might effect melamine is uric acid which we produce. We can control that, but we can't control melamine and MARC. And even if we eventually do pass most of it, what damage has it done in the meantime? Are damaged cells going to manifest into another issue? Is there residue that could cause cancer/tumors? Would the body be more apt to form stones due to trace or residue left in the body from uric acid that could be a forming point? Can the FDA answer any of these questions and back up the answer with facts?"



Here's the answer from Poco's post


Melamine and cyanuric acid combine
with strong hydrogen bonding giving rise to the crystals. These
crystals cause a physical blockage of individual nephron tubules,
starting where the collecting ducts empty into the calyx of the
kidney. These crystals start irritating the tubular epithelium
initiating morphologic changes causing the epithelial cells to
enlarge. As the crystals accumulate, they cause a physical blockage of
the individual tubules. When a sufficient number of tubules are
blocked, renal functions becomes impaired.
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