Very interesting article!  Many, many people think that APAP (and other OTC drugs, for that matter) is harmless, so they keep taking more than the recommended amounts. Not the case! I think that it needs to be made clearer on those compound cold medicines that they contain APAP too, which the FDA did not recommend, according to the article.

I'd think that older people, or others whose livers work less efficiently, would be at more risk of harm.

cato- I have the same reaction. Do better with naproxin too. I wish they would make all cold meds with it have a large warning ! Even 2 alchoholic drinks with APAP can cause liver damage.  A lot of rx meds can too & many people take both.

Oh no!  So many of my friends take Tylanol PMs! 

I cannot use any form of acetaminophen or ibuprofen due to a medical condition, but when I used it in the past, after 2 doses I would get flank pain.  That scared the heck out of me after I looked into it.  The only pain reliever I'm allowed to use is aspirin.  Thankfully, I only need it for a rare "lack of caffeine" headache.