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Pet Health (not to be substituted for qualified vet advice) => Feline Chronic Renal Failure and Insufficiency => Topic started by: Fizzy1 on November 23, 2015, 08:14:33 AM



Title: New lab test for CKD "SDMA"
Post by: Fizzy1 on November 23, 2015, 08:14:33 AM
A new test by IDEXX came out earlier this year that can be used along with BUN/Creatinine tests to assess kidney function.  The SDMA increases in cats with CKD on average 17 months earlier than creatinine, allowing earlier diagnosis and treatment.

https://www.idexx.com/files/small-animal-health/solutions/articles/intro-kidney-test-sdma.pdf


Title: Re: New lab test for CKD "SDMA"
Post by: Mandycat on November 23, 2015, 10:09:12 PM
Fizzy,
This new test introduced by Idexx is still not proven to be as much of a help as Idexx has been touting.  It could prompt some vets to prescribe some treatments for CKD far before they are needed, including encouraging the use of prescription kidney foods, which are actually very poor nutritionally for cats and really should not be used until the later stages of CKD.  The test does not actually take the place of the usual kidney function tests - Creatinine and BUN.  It is a "predictive" test, not a test telling current status of the kidneys.  We have found in the Yahoo Hyper-t Group that the tests have produced very conflicting results with some kitties who clearly did already have kidney disease having SDMA test results that indicated that they were not at risk for kidney disease!  I do not think this test is as reliable as it could be, but perhaps it will be improved upon.  Here is the link to an article written by one well-known veterinarian expressing some doubts about the usefulness of this new test.  Time will tell!

            http://www.petmd.com/blogs/thedailyvet/dr-coates/2015/may/how-helpful-new-kidney-test-dogs-and-cats-32725#


Title: Re: New lab test for CKD "SDMA"
Post by: Fizzy1 on November 23, 2015, 11:08:54 PM
Fizzy,
This new test introduced by Idexx is still not proven to be as much of a help as Idexx has been touting.  It could prompt some vets to prescribe some treatments for CKD far before they are needed, including encouraging the use of prescription kidney foods, which are actually very poor nutritionally for cats and really should not be used until the later stages of CKD.  The test does not actually take the place of the usual kidney function tests - Creatinine and BUN.  It is a "predictive" test, not a test telling current status of the kidneys.  We have found in the Yahoo Hyper-t Group that the tests have produced very conflicting results with some kitties who clearly did already have kidney disease having SDMA test results that indicated that they were not at risk for kidney disease!  I do not think this test is as reliable as it could be, but perhaps it will be improved upon.  Here is the link to an article written by one well-known veterinarian expressing some doubts about the usefulness of this new test.  Time will tell!

            http://www.petmd.com/blogs/thedailyvet/dr-coates/2015/may/how-helpful-new-kidney-test-dogs-and-cats-32725#


Thanks for the info.


Title: Re: New lab test for CKD "SDMA"
Post by: JoMax on January 15, 2016, 11:01:25 AM
Well it will be interesting to see how it goes - when I read about it on here back in November I asked about availability in UK and it had been released just a week before.  So I got Eppie tested since she is almost 17 and has been drinking loads for the last year. Results came back as really low (result was 14 - labs stated over 110 is worry point)

Previously we had been doing regular blood tests - then my vet suggested we did 3-monthly urine tests which she reckons is a better indicator as can get false readings from bloods - often she said the cat is ageing and eating less therefore breaking down body mass can look like there is a BUN problem.  Also better as easier than taking cat for bloods (as well as cheaper)

All tests show she is on OK side.  Will be interested to see how the test efficiency at disgnosis progresses - OK can lead to vets over prescribing on the food front - I pointed out to mine I didnt (and fussy-eater Eppie certainly wouldnt) go for this as option and she said if/when necessary we'd go with phos-binders & regular vitB & ACE inhibitors.

And unlike my angel Max, she would be a mare to force-feed, subq so the earliest interventions to postpone these the better.


Title: Re: New lab test for CKD "SDMA"
Post by: Mandycat on January 15, 2016, 09:55:36 PM
JoMax,
This test is really not a diagnostic test.  That is what is being missed by most people who hear about it.  It is a "predictive" test, or, at least it is suppose to be predictive.  It is suppose to show whether a particular cat is going to be prone to developing CKD in the future.  It is not really a test of what is happening NOW.  The experience so far on the Yahoo Hyper-t Group is that is not always very accurate.  We have had tests with low results on cats who have clearly had CKD for years.  We have had high tests on cats who have no indication of any kind of kidney issues.  Of course, that second group could prove to develop the problem in the future.  But, this test should only be used along with the usual BUN and Creatinine tests that have always been relied upon.  Yes, the urine USG can also be used to test kidney function, but it can have the same problems as the BUN and Creatinine in certain situations that would cause a cat to be drinking excessively, for instance, and thus result in dilute urine.  There is no one perfect test, so we have to take into consideration many factors, including other medical issues that a cat may have. 

I don't know if Idexx is reporting the test results in the same unit of measurement in the UK.  But, I'm glad the Eppie had a low result.


Title: Re: New lab test for CKD "SDMA"
Post by: JoMax on January 18, 2016, 09:25:15 AM
Thanks for info Mandycat - Prompts me to discuss at more length with my vet next time.  Hope more info/stats will be more widely available over here soon.